Join Date: Jun 2011
Location: East Central Iowa
OK, I'll make my contribution.
Start on the west side of the river at LaCrosse and follow the closest road to the river all the way down to the Iowa/Missouri border. You want to do Lansing, Harper's Ferry, McGregor, Guttenburg. Don't miss the left turn just south of the bridge at Millville or you'll miss maybe the best motorcycle road in Iowa. Continue south through Balltown(stop at Brietbachs for lunch) and Sherrill, once you get to hwy 52 at Dubuque stay on that and 67 all the way to Davenport/Rock Island, which is about as far south as I've been in that area.
All of these roads are normally in good to excellent condition, lightly traveled during the week and not real busy on weekends.
Can't help you much in Missouri, been a few years but I have traveled 218, and I know the route through Hannibal is popular. Just stay along the river, you can't screw up too bad.