I live in the general area and coming from Houston some of the best riding in the Arkansas area can be had by taking a few out of the way roads along your meandering way.
Meander up to Talihena, OK and take Hwy 271 and Hwy 1 north; Hwy 1 few miles north will split from Hwy 271 and Hwy 1 becomes the Talihena Drive:
And stay on the Talihena all the way into Mena or you will miss one of the best parts of the road.
Then in Mena, AR take hwy 71 north. About 8 miles north of Waldron, AR at a rest stop you will see Hwy 23 north. Take Hwy 23 north to Booneville, AR. At Booneville, AR turn right and follow Hwy 10 east to Havana, AR. At Havana turn left on Hwy 309 which will take you up and over Mount Magazine, the highest point in Arkansas:
Then continue north across the mountain on Hwy 309 and thru Paris, AR till you rejoin Hwy 23 north. At Ozark, AR if you have time to eat and like BBQ (which is better than anything I've got at BB&BBQ) I recommend:
I tend to like the ribs best there. Then continue up Hwy 23 which a few miles north of Ozark will become the PIGTRAIL:
The Pigtrail (Hwy 23) will lead you up to Eureka Springs, AR. Sometimes called "Little Switzerland." Eureka is nice esp for women; its too artsy fartsy for me but the ride there is what I enjoy the most.
Then there are several different ways back to Fayetteville for Bike, Blues and BBQ. None of the roads are bad.
If I were riding from the Houston area I'd probably try to stay a night or two along the way. There are rooms at the Queen Wilhemena Lodge, at Mt. Magazine Lodge and some nice Bed and Breakfast places at Eureka Springs. I'd have a reservation though during that time. One of the nice Bed and Breakfast in Eureka always scores points with females.
GOOD LUCK AND HAPPY TRAILS !!