From the valley I'd head 10W to Vicksburg Rd, 72 to 95 to Parker, 62 to Twenty-Nine Palms and Yucca Valley, 247 to Lucerne Valley. Can take 18 down around Big Bear Lake and onto 138. But this will put you north of LA - not a bad thing. Wind thru the Pasadena area and get to 27 (Topanga Canyon Rd) and take it down to Hwy 1.
Or 10W to Blythe then down 78 to Brawley and up thru Anza-Borrego into Julian and on to Ramona and into Dago.
Or take 8W to 94 (Ribbonwood Rd exit #65) and take it all the way to Spring Valley.
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Like I told you. What I said. Steal your face right off your head.