For the routes you suggest I would take the truck. Don't get me wrong, I have had to fly down the interstates a time or two to get to a work location in Texas or New Mexico, but then I took the back roads on the way home. I know what riding on the interstates is like and only do it if absolutely necessary because of time, but I make sure and find some enjoyable roads as well to make the trip worth it.
Google maps gives you great indicators of construction zones, traffic patterns, etc. Better resource than mapquest IMO.
This is the route I would take if I just wanted to get there. https://goo.gl/maps/MkdEQyH8HiG2
If you are set on interstates how about stopping for some of the sights along the way?
If you haven't been to Barbers Motorsports Museum just east of Birmingham, AL, I suggest you make that a stop on the way.
If you are into military history, Vicksburg National Military Park is worth a visit as well.
If you take your second route there are sights to see in Memphis if you are into the music scene or love BBQ.
You could also veer off and ride through Hot Springs, AR.
I have been using lists like this to help me when planning a route so I don't regret riding past a memorable road by staying on the interstate.
America?s Best Road Trips - MotorcycleRoads.com
With google maps you can pull the route off the interstate where you want to. https://goo.gl/maps/QVyacUBG6uv
Zoom in and you will see where I pulled you off to Barber's motorsports museum, and off I-20 onto 80 for a few miles.
Google maps also shows slowdowns along the routes in yellow and stops in red by tracking all the cell phones out there. You can check the route over the next few days at the times you think you might hit each city and see the traffic patterns.
You can also send the google maps route directly to your smartphone so you have it handy.
Have a great ride!
If you stay on the interstate through Arkansas you have robbed yourself of experiencing some fantastic roads and scenery.