It is difficult to head north from Tampa on an interesting route, until you get north of Atlanta. I have done it, a lot. My suggestion is taking 27 to Tallassee , 319 to Tifton, GA, then blast up 75 to north of Atlanta, and make your way north east to the Helen/Hiawassee, GA area, then over into western NC, then head west through the Cumberland Plateau area in TN to Nashville, avoiding interstates. Taking the Trace from Nashville to NOLA is great if you are not pressed for time. PM me and I will send specific routes through NC and TN.
John, Medina, TN - 2003 Honda ST1300 ABS, 2011 Kawasaki KLR 650, 2012 Ducati Monster 1100 EVO
2017 HD Road Glide Special