I've got a '16 FLTRUSE and added FullSac headers and Vance & Hines OS 450 Destroyers. Slightly louder/deeper at idle but when you roll that throttle and get into it, everyone will know. I've not had any issues on those longer trips, which I put 2,752 miles ride in 6 days in September '17.
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2016 CVO Road Glide Ultra - Ruby Red/Palladium Silver
"If you can park your bike without admiring it, then you've bought the wrong bike!"