I have a Fuel Moto mapped PC V on my 08, with Fuel Moto ac and jackpot slip ons. I have no complaints. I sat through a tech session on the autotune at the V-twin expo, though, and now I want one. I think that there are some worthwhile gains to be had from it, and rather than spend a bunch of hours on the dyno, I'd rather have it tune to my driving style, etc. The layout of the auto tune program is very cool, where you can set target air fuels by rpm, throttle position, and gear. As others have said, I'd like to be able to lean out my 6th gear cruise, to get some mileage back. And with the ability to change maps on the PC V, I think some neat stuff can be done. The shop I work for dyno tunes cars, and I wish we had a tool like this.
And the best part is that you could effectively use the auto tune to populate the maps, and then sell it, if you don't plan on making any other changes. I'm considering renting mine out when I'm done with it.