Unless you have an ancient amp you should be fine. The newer/better ones automatically detect load - when the resistance of the speakers is gone because they're disconnected no power is sent.
Freedom isn't free, remember to thank a vet.
2018 CVO RG lava orange, 117 Stage 3, 14" F47 and a few chrome extras. Boom crap gone.
2016 RG Special Cosmic Blue, 120ST with Dragos 2:1 and TTS tuner, FBI drop seat kit and JNR air ride. Stock audio long gone.