I am not a audio expert but that amp is a 4 channel amp and the audio system on the Harleys are 2 ohm systems so make sure it is compatible.
I would think that a 20 or 25 amp fuse would be sufficient, the main fuse on the bike is only 40 amp and the charging system is 50 amp max.
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08 FLTR candy red sunglo,with 2015 103 HO, V&H Dresser Duals with Monster Rounds, Power Vision tuner, Willy Shiny Wheels and Forks and a bunch of other stuff.