6-8 from Day-Naples only. I am down there for a week.
If you want mainly back roads, this is the way I go:
Rt 95 south to exit 202, rt524E
Right on 520
Left on 532
Left on 419
Right on 192
Left on 441
Right on 70 ( you can stay on 70 to 17 and 75 or continue)
Left on 31
Right on 80 ( crosses 75)
Left on Ortiz Ave
follow to Rt41 S
About 300 miles in 5 1/2 hours
There are many other ways, but this is back roads except for the 60 or so miles on 95. You can shorten the trip by taking more of 95, like to 192 or 70.