Very likely related to the exhaust gaskets and/or retaining clips. I would recommend replacing these items. There is nothing related to the system itself that would cause the flange nuts to loosen.I have a 2012 Road Glide Custom with a Jackpot 2 into 1 header, I have had a constant issue with the header bolts loosening when I ride. Has anyone else experienced the same issue??
I a thinking of switching to the Fullsack performance DX header. Any thoughts?